Antibacterial activity of 9-Aryl-6-(2-methoxyphenyl)-[1,2,4] triazolo [4,3-a][1,8]naphthyridines

Abstract

In this paper we describe the anti bacterial activity of newly synthesized derivatives of 9-Aryl-6-(2- methoxyphenyl)-[1,2,4]triazolo[4,3-a [1,8]naphthyridines(a-j) evaluated by the filter paper disc technique of Vincent and Vincent. The compounds were dissolved in acetone and tried at two different concentrations (250 and 500 g/disc). The Whatman filter paper discs (6 mm diameter) with different compounds were placed aseptically on seeded nutrient agar plates with different bacteria. The presence of substituents especially methyl, chloro, fluoro and dimethoxy groups when attached to phenyl ring increases the activity notably. Zone of inhibition was screened in mm.