DESIGN, SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL AND ANTIMALARIAL STUDIES OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES.

Authors

  • Mohit Lagdhir Chemistry Department, KSKV, Kadi.
  • Chintan Pandya Chemistry Department, HVHP Institute of PG Studies and Research,Kadi.
  • Aditee Pandya Microbiology Department, HVHP Institute of PG Studies and Research,Kadi.

Keywords:

Methyl-3-bromobenzoate,Quinoxaline-2-carboxylicacid,POCl3,Antimalarial Activity,Antimicrobial Activity.

Abstract

A new series of (3-(5-(quinoxalin-2-yl)-1,3,4-oxadiazol-2-yl) based phenyl aniline derivatives 6(A-L) are synthesized via preparation of hydrazide using hydrazine hydrate followed by formation of 1,3,4 oxadiazole using POCl3.The Final compound was synthesized via buchwald reaction. The final compounds were Analyzed by Spectroscopic Methods such as FT-IR, 1HNMR, LCMS and Mass Spectrometry as well as melting point measurement. All synthesized compounds were screened for antimicrobial activity against staphylococcus aureus, Bacillus megaterium, Escherichia coli & Proteus vulgaris.

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Published

2021-11-16

How to Cite

Lagdhir, M., Pandya, C., & Pandya, A. (2021). DESIGN, SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL AND ANTIMALARIAL STUDIES OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES. International Journal of Technical Innovation in Modern Engineering & Science, 4(6), 650–657. Retrieved from https://ijtimes.com/index.php/ijtimes/article/view/1667

Issue

Vol. 4 No. 6 (2018): Vol. 4 No. 6: Volume 4 Issue 6 (June-2018)

Section

Articles