“Solubility Study Of Formoterol Fumarate Dihydrate, Glycopyrrolate And Budesonide Drugs As A practical Tool For Analytical Method Development”

Authors

  • Ravindra K Kotak Kadisarva vishwavidyalaya, Gandhinagar-382015, Gujarat, India
  • Dr. Chintan V Pandya Department of chemistry, KSV university, Gandhinagar-382015, Gujarat, India.
  • Dr. Aditee C Pandya Department of chemistry, KSV university, Gandhinagar-382015, Gujarat, India.
  • Mr. Brajesh kumar Thakur Cadila Healthcare limited, Dept. Of Pulmonary-PTC,Moraiya, Ahmedabad, Gujarat, India.
  • Ms. Ritu Lahdda Cadila Healthcare limited, Dept. Of Pulmonary-PTC,Moraiya, Ahmedabad, Gujarat, India.

Keywords:

Solubility, Analytical method development, Metered dose inhalers, Dry powder inhaler, Chromatography

Abstract

All Drug molecules are Differ in their physical and Chemical properties. Any analytical method development will start with literature search and then the first practical step is to perform solubility analysis of drug which will be used as a basic information in Analytical method development for analysis of Different drugs in Different dosage forms. Here We selected Formoterol Fumarate Dihydrate, Glycopyrrolate and Budesonide drug molecules which are mainly used for treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and Asthma. Solubility analysis gives us information about type of chromatography can be used either Normal phase or Reverse phase. It also helps for Mobile phase and diluent selection for cost effective analytical method development. Water is a Universal solvent and Acetonitrile and Methanol are cheap and widely used solvents in Pharmaceutical industry. So, Here Water, Methanol and Acetonitrile solvents are used for the solubility study.

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Published

2019-05-01

How to Cite

Kotak, R. K. ., Pandya, D. C. V. ., Pandya, D. A. C. ., Thakur, M. B. kumar ., & Lahdda, M. R. . (2019). “Solubility Study Of Formoterol Fumarate Dihydrate, Glycopyrrolate And Budesonide Drugs As A practical Tool For Analytical Method Development”. International Journal of Technical Innovation in Modern Engineering & Science, 5(5), 386–388. Retrieved from https://ijtimes.com/index.php/ijtimes/article/view/2395

Issue

Vol. 5 No. 5 (2019): Vol. 5 No. 5: Volume 5 Issue 5 (May-2019)

Section

Articles