Concurrent Determination of Teneligliptin Hydrobromide Hydrate and Metformin Hydrochloride Development and Validation by UV-VIS Spectrophotometry in Bulk and Pharmaceutical Dosage Form.
Viral A. Patel
Department of chemistry- H.V.H.P Institute of post graduate studies and research, Kadi. KSV University, Gandhinagar, Gujarat, India. , IN
Dr. Chintan Pandya
Department of chemistry- H.V.H.P Institute of post graduate studies and research, Kadi. KSV University, Gandhinagar, Gujarat, India. , IN
Dr. Adeeti Pandya
Department of chemistry- H.V.H.P Institute of post graduate studies and research, Kadi. KSV University, Gandhinagar, Gujarat, India. , IN
Dr. Jasmin Kumbhani
Department of chemistry- H.V.H.P Institute of post graduate studies and research, Kadi. KSV University, Gandhinagar, Gujarat, India. , IN
Dharamesh Patel
Department of chemistry- H.V.H.P Institute of post graduate studies and research, Kadi. KSV University, Gandhinagar, Gujarat, India. , IN
Zalak Patel
Department of chemistry- H.V.H.P Institute of post graduate studies and research, Kadi. KSV University, Gandhinagar, Gujarat, India. , IN
Keywords: UV spectrophotometric, Teneligliptin Hydro bromide hydrate, Metformin Hydrochloride
Abstract
An easy, precise, exact, cost effective, reproducible and economical UV spectrophotometric methods was developed and validated for the simultaneous determination Teneligliptin Hydrobromide hydrate and Metformin Hydrochloride in tablet dosage form and pharmaceutical formulations. The method is based on choice of wavelengths; someplace one drug shows identical absorbance or variation between absorbance is zero and additional drug shows some reply. The wavelengths selected for use of Teneligliptin were 243 nm. While, wavelengths select for use of Metformin were 233 nm. Water was in used as solvent. Beer’s law was observing in the absorption range of 1.4 – 2.6 µg mL-1 for Teneligliptin and 35-65 µg mL-1 for Metformin. Development study for Teneligliptin and Metformin were performed and the percentage recovery for both the drugs were obtained in the range of 98.40-100.20% confirms the accuracy of the proposed method. The outcome woes verified that the procedure is accurate, precise and reproducible while being easy, not expensive and less time consuming and hence can be suitably applied for the estimation of Teneligliptin and Metformin in different dosage forms and successfully applied to determination of these drugs in commercial tablets.
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